5-Fluorouracil combined with the pure [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study of two consecutive regimens

Adv Exp Med Biol. 1993:339:81-95; discussion 97-8. doi: 10.1007/978-1-4615-2488-5_10.
No abstract available

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Clinical Trial, Phase II

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / drug therapy*
  • Dose-Response Relationship, Drug
  • Fluorouracil / administration & dosage
  • Folic Acid / blood
  • Folic Acid / pharmacokinetics
  • Follow-Up Studies
  • Humans
  • Leucovorin / administration & dosage
  • Middle Aged
  • Pyrimidines / administration & dosage
  • Stereoisomerism

Substances

  • Pyrimidines
  • Folic Acid
  • Leucovorin
  • Fluorouracil