Abstract
The synthesis and antifungal activities of some dichlorophenyl-1H-pyrrol-2-yl-1H-imidazol-1-ylmethane derivatives substituted at pyrrole nitrogen are reported. When tested against Candida albicans and Candida spp., some derivatives were found to be from two to four times less active than miconazole, bifonazole and ketoconazole, used as standard controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Candida / drug effects
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Candida albicans / drug effects
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
Substances
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Antifungal Agents
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Imidazoles
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Pyrroles