Treatment of FIGO stage Ib cervical carcinoma with nodal involvement

Eur J Gynaecol Oncol. 1994;15(1):59-64.

Abstract

One hundred and eighty one patients with stage Ib cervical cancer underwent hysterectomy with pelvic lymphadenectomy. The overall incidence of lymph node metastases was 20%. Twenty seven (71%) patients with nodal involvement were treated by external radiotherapy (TCT) and 11 (29%) by both chemotherapy and radiotherapy (Lin. Acc.). The overall survival at 5 years was 80%; it was 43% for patients with positive nodes and 89% for patients without metastatic nodal disease. The 3 year survival of patients with positive nodes who underwent radiation therapy by TCT was 58%, while it was 72% for those treated by chemotherapy plus radiotherapy. We observed a recurrence in 23% of the cases, 52% in patients with positive nodes and 15% in those with negative nodes. The association chemo-radiotherapy in patients with metastatic lymph nodes seems to improve the survival and reduce the recurrence rate.

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / secondary
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Brachytherapy
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / surgery
  • Cesium Radioisotopes / therapeutic use
  • Chemotherapy, Adjuvant
  • Cisplatin / therapeutic use
  • Combined Modality Therapy
  • Female
  • Humans
  • Hysterectomy
  • Lymph Node Excision
  • Lymphatic Metastasis / pathology*
  • Lymphatic Metastasis / radiotherapy
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Radiotherapy, High-Energy
  • Retrospective Studies
  • Survival Rate
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / radiotherapy
  • Uterine Cervical Neoplasms / surgery*

Substances

  • Cesium Radioisotopes
  • Cisplatin