Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model

Radiother Oncol. 1993 Jul;28(1):69-71. doi: 10.1016/0167-8140(93)90188-e.

Abstract

CDF1 mice were allowed to breathe either oxygen, carbogen or different concentrations of carbon monoxide gas. These treatments significantly altered the percentage of clonogenic hypoxic cells in a C3H mouse mammary carcinoma and these changes were found to correlate with direct measurements of tumour oxygenation obtained using an Eppendorf pO2 electrode.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Dioxide / administration & dosage
  • Cell Hypoxia
  • Female
  • Male
  • Mammary Neoplasms, Experimental / metabolism*
  • Mammary Neoplasms, Experimental / radiotherapy*
  • Mice
  • Mice, Inbred Strains
  • Oxygen / metabolism*
  • Respiration

Substances

  • Carbon Dioxide
  • Oxygen