Interleukin-7, a major T-lymphocyte cytokine

Eur Cytokine Netw. 1993 Jul-Aug;4(4):253-62.

Abstract

IL-7 is a single-chain 25 kDa protein first identified in bone marrow cultures through its pre-B cell growth factor properties, then also described as a potent T-lymphocyte growth factor. This review relates to the molecular and functional aspects of interleukin-7 (IL-7) and its receptor (IL-7R). We focused on the role of IL-7 in T-cell activation, cytotoxicity generation, leukemic cell growth and immunotherapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Cytotoxicity, Immunologic / physiology
  • Genes
  • Graft Rejection
  • Humans
  • Interleukin-7 / biosynthesis
  • Interleukin-7 / genetics
  • Interleukin-7 / physiology*
  • Leukemia / pathology
  • Lymphocyte Activation / physiology
  • Mice
  • Molecular Sequence Data
  • Neoplasm Transplantation
  • Neoplastic Stem Cells / drug effects
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / physiology
  • Receptors, Interleukin-7
  • Recombinant Proteins / biosynthesis
  • Sequence Homology
  • Signal Transduction
  • T-Lymphocytes / physiology
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / transplantation

Substances

  • Interleukin-7
  • Receptors, Interleukin
  • Receptors, Interleukin-7
  • Recombinant Proteins