Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties

J Antibiot (Tokyo). 1993 Nov;46(11):1648-57. doi: 10.7164/antibiotics.46.1648.

Abstract

A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors*
  • Animals
  • Benzoates / chemistry
  • Benzoates / isolation & purification*
  • Benzoates / pharmacology*
  • Dogs
  • Fermentation
  • Fusarium / chemistry*
  • Galactosides / chemistry
  • Galactosides / isolation & purification*
  • Galactosides / pharmacology*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Salicylates
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
  • Swine

Substances

  • Benzoates
  • Galactosides
  • Salicylates
  • aquastatin A
  • Adenosine Triphosphatases
  • Sodium-Potassium-Exchanging ATPase