The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13

Genomics. 1993 Oct;18(1):148-50. doi: 10.1006/geno.1993.1441.

Abstract

The leukemia inhibitory factor receptor (LIFR) gene was localized to human chromosome 5p12-p13 by somatic cell hybrid analysis. Interspecific backcross analysis revealed that the murine locus was on chromosome 15 in a region of homology with human chromosome 5p. In both human and mouse genomes, the LIFR locus was linked to the genes encoding the receptors for interleukin-7, prolactin, and growth hormone.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5*
  • Growth Hormone / genetics
  • Growth Inhibitors*
  • Humans
  • Hybrid Cells
  • Interleukin-6*
  • Interleukin-7 / genetics
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lymphokines / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Multigene Family
  • Prolactin / genetics
  • Receptors, Cytokine / genetics*
  • Receptors, OSM-LIF

Substances

  • Growth Inhibitors
  • Interleukin-6
  • Interleukin-7
  • LIF protein, human
  • LIFR protein, human
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lif protein, mouse
  • Lifr protein, mouse
  • Lymphokines
  • Receptors, Cytokine
  • Receptors, OSM-LIF
  • Prolactin
  • Growth Hormone