Objective: We applied glucose loading during PET studies with [18F]2-fluoro-2-deoxy-D-glucose (FDG) to enhance detection of brain tumors by diminution of FDG uptake in normal gray matter.
Materials and methods: This study involved three patients with glioblastomas. Two PET scans were performed in all cases within 1 week in control and with glucose loading state.
Results: In all patients, tumor was depicted more clearly with glucose loading than in the control study. The FDG uptake ratio of tumor to normal cortical gray matter showed a mean increase of 27% with glucose loading.
Conclusion: This technique might be useful for detection of recurrent or residual tumors.