Twenty-one patients with ischemic heart disease were studied by resting 99mTc-methoxyisobutyl isonitrile (MIBI) gated SPECT images using a 3 head rotating gamma camera (Picker/Shimadzu: PRISM 3000). The data were acquired over 360 degrees in 20 (x 3) steps, each of which was 70 beats. The systolic wall thickening index (%WT) was calculated as (ES count-ED count/ED count x 100), using the circumferential profile analysis of ED and ES short axial images. The %WT was correlated well with LVEF obtained from contrast ventriculography (r = 0.85, n = 17). By using high speed (3 head) rotating gamma camera, we have shortened the time of collecting MIBI gated SPECT data, and this method can provide useful information on ventricular function.