1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, selective uptake by B-16 melanoma, and selective cytotoxicity toward cancer cells

Y Yamamoto; H Nakamura

doi:10.1021/jm00067a021

1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, selective uptake by B-16 melanoma, and selective cytotoxicity toward cancer cells

J Med Chem. 1993 Jul 23;36(15):2232-4. doi: 10.1021/jm00067a021.

Authors

Y Yamamoto¹, H Nakamura

Affiliation

¹ Department of Chemistry, Faculty of Science, Tohoku University, Sendai, Japan.

PMID: 8340924
DOI: 10.1021/jm00067a021

Abstract

1-Carboranyl-3-(2-methylaziridino)-2-propanol (MACB) was prepared from the reaction of 1-carboranyl-2,3-epoxypropane with metalated methylaziridines having copper [Cu(CN)Li2]1/2 or lead (PbBu3) as the metal. MACB exhibited relatively high growth inhibition toward some cancer cells, and selective uptake of MACB by B-16 melanoma was accomplished.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacokinetics
Antineoplastic Agents / pharmacology
Aziridines / chemical synthesis*
Humans
Melanoma, Experimental / drug therapy
Melanoma, Experimental / metabolism
Propanols*
Structure-Activity Relationship
Tumor Cells, Cultured / drug effects

Substances

Antineoplastic Agents
Aziridines
Propanols