Fifteen thousand patients were studied consecutively at the Echocardiographic Laboratory in the University Hospital Calixto García. We found that one out of 1,500 patients studied (0.07%) presented a cardiac myxoma. Average age 40.8 years. Male sex was mainly (60%), and the interval between the onset of the symptoms and the diagnosis was 22.8 months. A previous diagnosis to Echo was performed in 30% of the patients despite of the recurrency and refractory therapeutics of symptoms. The echocardiographic data showed that left atrium and right ventricle dilatation were proportionally related to the tumor size and its mitral obstruction degree since 90% was localized at the left interatrial septum, and was presented at right ventricle septum and in both auricles in 2 patients. All the patients were successfully surgical treated and the 4-year Echo 2D study showed no tumoral recurrency.