Abstract
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
MeSH terms
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Animals
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Antibiotics, Antineoplastic* / chemistry
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Antibiotics, Antineoplastic* / isolation & purification
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Antibiotics, Antineoplastic* / pharmacology
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Ascomycota / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Drug Screening Assays, Antitumor
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Fermentation
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Humans
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Mice
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Molecular Structure
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Tropolone / analogs & derivatives*
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Tropolone / chemistry
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Tropolone / isolation & purification
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Tropolone / pharmacology
Substances
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Antibiotics, Antineoplastic
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eupenifeldin
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Tropolone