[Potentiation of cytotoxicity of anticancer drugs by flavone acetic acid]

Gan To Kagaku Ryoho. 1993 Aug;20(11):1570-1.
[Article in Japanese]

Abstract

We used B 16 melanoma cells both in vitro and in vivo to determine whether Flavone acetic acid (FAA) can increase the cytotoxicity of mitomycin C (MMC) under normothermic and hyperthermic (HT) conditions. The significantly increased cytotoxicity of MMC combined with FAA and HT seems to be mainly related to activation of alkylating species under FAA mediated hypoxic condition.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Combined Modality Therapy
  • Drug Synergism
  • Flavonoids / pharmacology*
  • Hyperthermia, Induced*
  • Male
  • Melanoma, Experimental / pathology*
  • Mice
  • Mitomycin / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Flavonoids
  • Mitomycin
  • flavone acetic acid