Uterine cervical lymphoepithelial-like carcinoma. Absence of Epstein-Barr virus genomes

Am J Clin Pathol. 1993 Feb;99(2):195-9. doi: 10.1093/ajcp/99.2.195.

Abstract

A poorly differentiated squamous cell carcinoma of the cervix with marked lymphoplasmacytic stromal infiltration is described in a 21-year-old black woman who had postcoital bleeding. Histologic features were strikingly similar to the classic lymphoepithelioma of the nasopharynx. Serologic evidence for remote Epstein-Barr virus infection was present. However, polymerase chain reaction amplification and hybridization of DNA extracted from fresh-frozen tumor tissue failed to identify Epstein-Barr virus genomic DNA. No human papillomavirus DNA was detected by polymerase chain reaction amplification. The histologic and Epstein-Barr virus results of the uterine cervical lymphoepitheliomal-like carcinoma were compared to the classic nasopharyngeal lymphoepithelioma and to similar tumors studied from other anatomic sites.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology*
  • DNA, Neoplasm / genetics
  • DNA, Viral / analysis
  • Female
  • Genome, Viral*
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Polymerase Chain Reaction
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / pathology
  • Uterine Cervical Neoplasms / genetics
  • Uterine Cervical Neoplasms / pathology*

Substances

  • DNA, Neoplasm
  • DNA, Viral