Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method

Antimicrob Agents Chemother. 1993 Feb;37(2):339-41. doi: 10.1128/AAC.37.2.339.

Abstract

The synergistic activity of levofloxacin and oxacillin against levofloxacin-resistant isolates of methicillin-resistant Staphylococcus aureus was tested by the time-kill method. The combination of levofloxacin at 1/4 the MIC for the isolate plus oxacillin at 8 micrograms/ml (< 1/4 the MIC) was synergistic against seven of nine isolates at 8 h, although no significant synergy was demonstrated at 24 h. This combination may prove to be effective against multidrug-resistant methicillin-resistant S. aureus, and further studies are warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Drug Resistance, Microbial
  • Drug Synergism
  • Kinetics
  • Levofloxacin*
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Ofloxacin / pharmacology*
  • Oxacillin / pharmacology*
  • Staphylococcus aureus / drug effects*

Substances

  • Anti-Infective Agents
  • Levofloxacin
  • Ofloxacin
  • Oxacillin