Comparative toxicity and pathology associated with administration of recombinant HuIL-1 alpha to animals

MeSH terms

• Adrenal Cortex / drug effects
• Adrenal Cortex / pathology
• Animals
• Blood Cell Count / drug effects
• Bone and Bones / drug effects
• Bone and Bones / pathology
• Chlorocebus aethiops
• Dogs
• Eye / drug effects
• Eye / pathology
• Female
• Fever / chemically induced
• Fibrinolysis / drug effects
• Hematopoiesis / drug effects
• Humans
• Interleukin-1 / pharmacology
• Interleukin-1 / toxicity*
• Macaca fascicularis
• Male
• Mice
• Mice, Inbred C57BL
• Myocarditis / chemically induced
• Myocarditis / pathology
• Recombinant Fusion Proteins / pharmacology
• Recombinant Fusion Proteins / toxicity*
• Species Specificity
• Splenomegaly / chemically induced
• Splenomegaly / pathology
• Viscera / drug effects
• Viscera / pathology
• Weight Loss / drug effects