Abstract
Some 3-triazenopyrroles were prepared by coupling 3-diazopyrroles and secondary amines. In preliminary in vitro screening tests derivatives 3 showed to be cytotoxic and exhibited mutagenic effects.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / toxicity
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Cell Survival / drug effects
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Friend murine leukemia virus
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Lethal Dose 50
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Leukemia, Erythroblastic, Acute / drug therapy
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Melanoma, Experimental / drug therapy
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Mice
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Mice, Inbred DBA
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Pyrroles / toxicity
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Triazines / chemical synthesis*
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Triazines / pharmacology
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Triazines / toxicity
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Pyrroles
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Triazines