Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes

Nucl Med Biol. 1993 May;20(4):407-12. doi: 10.1016/0969-8051(93)90071-2.

Abstract

For passive targeting of liposomes to tumor tissues, we earlier developed reticuloendothelial system (RES)-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide (PGlcUA). In the present study, we encapsulated technetium-99m (99mTc)-diethylenetriaminepentaacetic acid (DTPA) in PGlcUA-liposomes (dipalmitoylphosphatidylcholine:cholesterol:PGlcUA = 40:40:20 as a molar ratio) and studied the biodistribution of the liposomes in tumor-bearing mice. 99mTc-DTPA encapsulated in liposomes effectively accumulated in tumor tissues after intravenous administration. Corresponding to these results, tumor was strongly imaged by a gamma-camera when 99mTc-DTPA-encapsulated PGlcUA-liposomes were used.

Publication types

  • Comparative Study

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine
  • Animals
  • Drug Carriers
  • Gamma Cameras
  • Injections, Intravenous
  • Liposomes
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mononuclear Phagocyte System / metabolism*
  • Phosphatidylglycerols
  • Radionuclide Imaging
  • Sarcoma 180 / diagnostic imaging*
  • Sarcoma 180 / metabolism
  • Technetium Tc 99m Pentetate / administration & dosage*
  • Technetium Tc 99m Pentetate / pharmacokinetics
  • Tissue Distribution

Substances

  • Drug Carriers
  • Liposomes
  • Phosphatidylglycerols
  • 1,2-Dipalmitoylphosphatidylcholine
  • 1,2-dipalmitoylphosphatidylglycerol
  • Technetium Tc 99m Pentetate