A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2)

Inflamm Res. 1995 Aug:44 Suppl 2:S145-6. doi: 10.1007/BF01778304.
No abstract available

MeSH terms

  • Animals
  • Cyclooxygenase Inhibitors / pharmacology*
  • Edema / chemically induced
  • Edema / drug therapy
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism*
  • Male
  • Mice
  • Nitrobenzenes / pharmacology*
  • Prostaglandin-Endoperoxide Synthases / chemistry
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Sulfonamides / pharmacology*

Substances

  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Nitrobenzenes
  • Sulfonamides
  • N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
  • Prostaglandin-Endoperoxide Synthases