The African swine fever virus IAP homolog is a late structural polypeptide

Virology. 1995 Dec 20;214(2):670-4. doi: 10.1006/viro.1995.0083.

Abstract

The analysis of the complete nucleotide sequence of the African swine fever virus genome has revealed the existence of a number of genes potentially capable of modifying the host's response to the virus infection. In this report, we describe the results of the characterization of the A224L gene that encodes a novel member of the family of apoptosis inhibitors known as IAP proteins. A224L is expressed during the late phase of the infectious cycle, and its polypeptide product is assembled into virus particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • African Swine Fever Virus / chemistry*
  • African Swine Fever Virus / genetics
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line, Transformed
  • Chlorocebus aethiops
  • DNA, Viral
  • Inhibitor of Apoptosis Proteins
  • Molecular Sequence Data
  • RNA, Viral / metabolism
  • Sequence Homology, Amino Acid
  • Vero Cells
  • Viral Proteins / chemistry
  • Viral Structural Proteins / chemistry*
  • Viral Structural Proteins / genetics

Substances

  • A224L protein, African swine fever virus
  • DNA, Viral
  • Inhibitor of Apoptosis Proteins
  • RNA, Viral
  • Viral Proteins
  • Viral Structural Proteins
  • inhibitor of apoptosis, Nucleopolyhedrovirus