Tumour targeting of the anti-ovarian carcinoma x anti-CD3/TCR bispesific monoclonal antibody OC/TR and its parental MOv18 antibody in experimental ovarian cancer

Anticancer Res. 1995 Sep-Oct;15(5B):2169-74.

Abstract

The anti-tumour x anti-T-cell bispecific monoclonal antibody (biMAb) OC/TR is a biologically produced biMAb combining the anti-ovarian carcinoma activity of the MOv18 MAb with anti-CD3/T-cell receptor (TCR) complex activity. In this study, the in vitro binding characteristics of the OC/TR biMAb and its tumour targeting potential in nude mice with Hela tumours was studied. Scatchard analysis revealed that the affinity constant of the biMAb was 7 times lower than the affinity of the parental MOv18 antibody. Uptake of the OC/TR antibody in the Hela xenografts in nude mice was significantly higher than the tumour uptake of an irrelevant control antibody, indicating that the radioiodinated OC/TR biMAb specifically localized in the tumour xenografts. However, tumour uptake was significantly lower than the tumour uptake of the parental MOv18 antibody. This reduced tumour uptake most likely is a result of its reduced affinity. We conclude that, despite the loss of bivalent tumour cell binding, the biMAb OC/TR can still specifically localize in tumours. This indicates that the first prerequisite of an effective therapeutic approach using systemically applied biMAb can be met. Whether the interaction with human T-cells will affect the tumour targeting potential of the biMAb in patients remains to be investigated.

MeSH terms

  • Animals
  • Antibodies, Bispecific / pharmacokinetics*
  • Antibodies, Bispecific / therapeutic use
  • Antibodies, Monoclonal / pharmacokinetics*
  • Antibodies, Monoclonal / therapeutic use
  • Female
  • Humans
  • Iodine Radioisotopes
  • Isotope Labeling
  • Mice
  • Mice, Inbred BALB C
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / therapy*
  • Receptor-CD3 Complex, Antigen, T-Cell / immunology*
  • Tissue Distribution
  • Tumor Cells, Cultured

Substances

  • Antibodies, Bispecific
  • Antibodies, Monoclonal
  • Iodine Radioisotopes
  • Receptor-CD3 Complex, Antigen, T-Cell