Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors

J B Kramer; T Capiris; J C Sircar; D T Connor; D A Bornemeier; R D Dyer; P J Kuipers; J A Kennedy; C D Wright; G C Okonkwo

doi:10.1016/0968-0896(95)00027-e

Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors

Bioorg Med Chem. 1995 Apr;3(4):403-10. doi: 10.1016/0968-0896(95)00027-e.

Authors

J B Kramer¹, T Capiris, J C Sircar, D T Connor, D A Bornemeier, R D Dyer, P J Kuipers, J A Kennedy, C D Wright, G C Okonkwo, et al.

Affiliation

¹ Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.

PMID: 8581424
DOI: 10.1016/0968-0896(95)00027-e

Abstract

The preparation of hydroxylamine analogs of 2,6-di-tert-butylphenols (DTBP) and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is discussed.

MeSH terms

Alkylation
Benzophenones / chemistry
Benzophenones / pharmacology
Cyclooxygenase Inhibitors / chemical synthesis
Cyclooxygenase Inhibitors / chemistry*
Cyclooxygenase Inhibitors / pharmacology
Humans
Hydroxylamine
Hydroxylamines / chemistry*
Lipoxygenase Inhibitors*
Oxidation-Reduction
Oximes / chemistry
Oximes / pharmacology
Phenols / chemistry*
Phenols / pharmacology
Structure-Activity Relationship
Vasodilator Agents

Substances

Benzophenones
Cyclooxygenase Inhibitors
Hydroxylamines
Lipoxygenase Inhibitors
Oximes
Phenols
TZI 41078
Vasodilator Agents
2,6-di-tert-butylphenol
Hydroxylamine