Fast axonal transport rates are unchanged in 6- and 24-month F344 rats

J M Jacob

doi:10.1016/0006-8993(95)01051-v

Fast axonal transport rates are unchanged in 6- and 24-month F344 rats

Brain Res. 1995 Nov 13;699(1):154-6. doi: 10.1016/0006-8993(95)01051-v.

Author

J M Jacob¹

Affiliation

¹ Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City 73104, USA.

PMID: 8616607
DOI: 10.1016/0006-8993(95)01051-v

Abstract

The maximum rate of fast axonal transport in motor axons at 6 and 24 months was measured in F344 rats. Tritiated proline was injected near sciatic motoneurons and rats were killed after 2-5 h. Nerves were processed for liquid scintillation spectroscopy and fast transport rates calculated. The rates, in 6- and 24-month rats, were 373 +/- 12 mm/day and 368 +/- 10 mm/day, respectively. Thus, the maximum fast transport rate is unchanged with age in F344 rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Aging / metabolism*
Animals
Axons / physiology*
Male
Proline / metabolism*
Rats
Rats, Inbred F344
Sciatic Nerve / physiology*
Time Factors

Substances

Proline