Abstract
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibodies, Monoclonal / chemistry
-
Antibody Specificity
-
Binding Sites, Antibody
-
Binding, Competitive / immunology
-
Clone Cells
-
HLA-A3 Antigen / immunology*
-
HLA-A3 Antigen / pharmacology
-
Humans
-
Immunoglobulin G / chemistry
-
Killer Cells, Natural / immunology
-
Killer Cells, Natural / metabolism
-
Receptors, Immunologic / chemistry*
-
Receptors, Immunologic / immunology*
-
Receptors, KIR
-
Receptors, KIR3DL2
-
T-Lymphocytes / metabolism
Substances
-
Antibodies, Monoclonal
-
HLA-A3 Antigen
-
Immunoglobulin G
-
KIR3DL2 protein, human
-
Receptors, Immunologic
-
Receptors, KIR
-
Receptors, KIR3DL2