Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain

Brain Res. 1995 Nov 27;700(1-2):285-8. doi: 10.1016/0006-8993(95)01053-x.

Abstract

We studied immunohistochemically the 22 kDa peroxisomal membrane protein (PMP 22). In the control brain, the immunopositive neurons for PMP 22 appeared 2-3 weeks earlier than those for peroxisomal enzymes. PMP 22-immunopositive glial cells appeared at 26-27 gestational weeks, increased with gestational age, and were rarely recognized after 1 year of age. In the patients with Zellweger syndrome, PMP 22-immunoreactivity was recognized in neurons, glias, liver and kidney cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / embryology
  • Brain / growth & development
  • Brain / metabolism*
  • Cerebellum / chemistry
  • Embryonic and Fetal Development / physiology
  • Frontal Lobe / chemistry
  • Gestational Age
  • Humans
  • Immunohistochemistry
  • Infant
  • Kidney / chemistry
  • Kidney / cytology
  • Liver / chemistry
  • Liver / cytology
  • Membrane Proteins / analysis*
  • Microbodies / chemistry*
  • Molecular Weight
  • Neuroglia / chemistry
  • Neurons / chemistry
  • Organ Specificity / physiology

Substances

  • Membrane Proteins
  • PXMP2 protein, human