Abstract
Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early in diabetogenesis, because "preclinical" individuals also showed linkage. Human leukocyte antigen (HLA)-disparate, but not HLA-identical, sibs showed linkage, which was even stronger in families with affected females. The genes encoding insulin-like growth factor-binding proteins 2 and 5 were mapped to a 4-megabase pair interval near this locus. These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Animals
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Autoantibodies / analysis
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Chromosome Mapping
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Chromosomes, Human, Pair 2 / genetics*
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Diabetes Mellitus, Type 1 / genetics*
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Female
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Gene Frequency
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Genetic Linkage*
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Genetic Markers*
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Genetic Predisposition to Disease
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HLA Antigens / genetics
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Humans
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Insulin-Like Growth Factor Binding Protein 2 / genetics
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Insulin-Like Growth Factor Binding Protein 5 / genetics
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Islets of Langerhans / immunology
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Male
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Mice
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Mice, Inbred NOD / genetics
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Microsatellite Repeats
Substances
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Autoantibodies
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Genetic Markers
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HLA Antigens
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Insulin-Like Growth Factor Binding Protein 2
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Insulin-Like Growth Factor Binding Protein 5
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islet cell antibody