The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region

Int J Obes Relat Metab Disord. 1996 Mar;20(3):278-9.

Abstract

The polymorphic Bcl I site in the human ucp gene associated to percentage fat gain over time in the Québec Family Study cohort (Oppert et al. Int J Obesity 1994; 18: 526-531) has been positioned to the 5'-flanking region. This polymorphism results from a unique A/G mutation. Oligonucleotides used to amplify the polymorphic region, and allowing future studies of any cohort of patients, are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Carrier Proteins / genetics*
  • DNA / chemistry*
  • Deoxyribonucleases, Type II Site-Specific / metabolism*
  • Humans
  • Ion Channels
  • Membrane Proteins / genetics*
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Obesity / genetics
  • Point Mutation*
  • Polymorphism, Restriction Fragment Length*
  • Restriction Mapping
  • Uncoupling Protein 1

Substances

  • Carrier Proteins
  • Ion Channels
  • Membrane Proteins
  • Mitochondrial Proteins
  • Uncoupling Protein 1
  • DNA
  • endodeoxyribonuclease BclI
  • Deoxyribonucleases, Type II Site-Specific

Associated data

  • GENBANK/U28479