Abstract
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation
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Humans
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Immunoglobulin E / biosynthesis
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Immunoglobulin E / immunology
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Interferon-gamma / biosynthesis
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Interleukin-13 / biosynthesis
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Interleukin-13 / immunology
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Interleukin-4 / biosynthesis
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Interleukin-4 / immunology
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Lymphocyte Activation*
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Mice
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Mice, SCID
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Models, Immunological
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Receptors, Interleukin / antagonists & inhibitors*
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Th2 Cells / immunology*
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Th2 Cells / metabolism*
Substances
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Interleukin-13
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Receptors, Interleukin
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Interleukin-4
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Immunoglobulin E
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Interferon-gamma