[Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers]

Bull Cancer Radiother. 1996;83(1):12-6.
[Article in French]

Abstract

Second primary cancers often occur in head and neck cancer patients successfully treated by radiation therapy. Experimental and epidemiological data suggest that these second primaries might be prevented by antioxidant vitamins, in particular beta-carotene and alpha-tocopherol. A randomized double-blind clinical trial is being conducted in Canada to determine whether vitamin supplementation with beta-carotene (30 mg/d) and alpha-tocopherol (400 IU/d) reduces the incidence of second primaries in head and neck cancer patients treated by radiation therapy.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acetylcysteine / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Antioxidants / therapeutic use
  • Carcinoma, Squamous Cell / diet therapy*
  • Carcinoma, Squamous Cell / pathology
  • Carotenoids / administration & dosage
  • Follow-Up Studies
  • Head and Neck Neoplasms / diet therapy*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Neoplasm Staging
  • Neoplasms, Second Primary / prevention & control*
  • Risk Factors
  • Vegetables
  • Vitamin A / administration & dosage
  • Vitamin E / administration & dosage
  • Vitamins / therapeutic use*
  • beta Carotene

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Vitamins
  • beta Carotene
  • Vitamin A
  • Vitamin E
  • Carotenoids
  • Acetylcysteine