First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme

J Med Chem. 1996 Jun 21;39(13):2438-40. doi: 10.1021/jm9601516.

Authors

R E Dolle¹, C P Prouty, C V Prasad, E Cook, A Saha, T M Ross, J M Salvino, C T Helaszek, M A Ator

Affiliation

¹ Sanofi Winthrop Inc., Collegeville, Pennsylvania 19426, USA.

PMID: 8691439
DOI: 10.1021/jm9601516

No abstract available

MeSH terms

Amino Acid Sequence
Caspase 1
Cysteine Endopeptidases / metabolism*
Cysteine Proteinase Inhibitors / chemical synthesis*
Cysteine Proteinase Inhibitors / chemistry
Cysteine Proteinase Inhibitors / pharmacology
Drug Design
Hydrogen Bonding
Interleukin-1 / metabolism
Kinetics
Molecular Sequence Data
Molecular Structure
Oligopeptides / chemical synthesis*
Oligopeptides / pharmacology
Pyrimidines / chemical synthesis
Pyrimidines / pharmacology

Substances

Cysteine Proteinase Inhibitors
Interleukin-1
Oligopeptides
Pyrimidines
Cysteine Endopeptidases
Caspase 1