NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs

Neurochem Int. 1996 Feb;28(2):189-92. doi: 10.1016/0197-0186(95)00070-4.

Abstract

Using quantitative in situ hybridization, a significant decrease in expression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperitoneal administration of N-methyl-D-aspartate receptor antagonist MK-801, 2 mg/kg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Dizocilpine Maleate / administration & dosage
  • Dizocilpine Maleate / pharmacology*
  • Down-Regulation / drug effects
  • Enkephalins / biosynthesis*
  • Excitatory Amino Acid Antagonists / administration & dosage
  • Excitatory Amino Acid Antagonists / pharmacology*
  • In Situ Hybridization
  • Injections, Intraperitoneal
  • Male
  • Neostriatum / drug effects
  • Neostriatum / metabolism*
  • Protein Precursors / biosynthesis*
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Wistar
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
  • Tachykinins / biosynthesis*

Substances

  • Enkephalins
  • Excitatory Amino Acid Antagonists
  • Protein Precursors
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate
  • Tachykinins
  • proenkephalin
  • protachykinin
  • Dizocilpine Maleate