Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia

V Soenen; M Chaffanet; C Preudhomme; A Dib; J L Lai; J A Fletcher; D Birnbaurn; M J Pébusque

doi:10.1002/(SICI)1098-2264(199603)15:3<191::AID-GCC9>3.0.CO;2-Y

Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia

Genes Chromosomes Cancer. 1996 Mar;15(3):191-4. doi: 10.1002/(SICI)1098-2264(199603)15:3<191::AID-GCC9>3.0.CO;2-Y.

Authors

V Soenen¹, M Chaffanet, C Preudhomme, A Dib, J L Lai, J A Fletcher, D Birnbaurn, M J Pébusque

Affiliation

¹ Laboratoire d'Hématologie, Höpital Calmettes, Lille, France.

PMID: 8721686
DOI: 10.1002/(SICI)1098-2264(199603)15:3<191::AID-GCC9>3.0.CO;2-Y

Abstract

Using a series of yeast artificial chromosomes (YAC) from the Bp11-12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow / pathology
Chromosome Banding
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 8*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Monocytic, Acute / genetics*
Leukemia, Monocytic, Acute / pathology
Leukemia, Myelomonocytic, Acute / genetics*
Leukemia, Myelomonocytic, Acute / pathology
Translocation, Genetic*