While the definition of asthma is based on clinical manifestations and respiratory function, imaging is widely used in acute asthma. We attempted to exploit the resources of high-resolution computed tomography to better study the fine structure of the airways. In acute asthma and at the first consultation for asthma, standard radiograms provide little precise information on the bronchi excepting cases with major lesions. High-resolution computed tomography can identify persistent bronchial and lung lesions which significantly correlate with clinical expression. These lesions are more frequent in non-allergic persons. We were able to obtain dynamic images demonstrating the anatomic variations in bronchial obstruction occurring after a provocation test. These applications are now in the clinical research stage. High-resolution computed tomography may soon play a role in clinical management of patients with asthma.