Precise localization of the human gene encoding cell adhesion kinase beta (CAK beta/PYK2) to chromosome 8 at p21.1 by fluorescence in situ hybridization

Hum Genet. 1996 Oct;98(4):508-10. doi: 10.1007/s004390050249.

Abstract

Cell adhesion kinase beta (CAK beta) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily with large N- and C-domains in addition to the central kinase domain. The cDNA of the human CAK beta has been cloned and used as a probe for the assignment of this gene by fluorescence in situ hybridization. CAK beta is sublocalized on chromosome 8p21.1, a locus frequently involved in allelic losses in colorectal cancers and prostate carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 8*
  • Colorectal Neoplasms / genetics
  • DNA Probes
  • DNA, Complementary
  • Focal Adhesion Kinase 2
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Male
  • Molecular Sequence Data
  • Prostatic Neoplasms / genetics
  • Protein-Tyrosine Kinases / genetics*
  • Rats

Substances

  • DNA Probes
  • DNA, Complementary
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 2
  • Ptk2b protein, rat

Associated data

  • GENBANK/L49207
  • GENBANK/U43522