Abstract
The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Arousal* / physiology
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Attention* / physiology
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Cognition Disorders / diagnosis
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Cognition Disorders / physiopathology
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Cognition Disorders / psychology
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Dextroamphetamine*
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Dopamine / physiology
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Dopamine Agents*
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Female
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Humans
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Male
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Middle Aged
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Neuropsychological Tests*
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Norepinephrine / physiology
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Problem Solving / physiology
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Schizophrenia / diagnosis
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Schizophrenia / physiopathology
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Schizotypal Personality Disorder / diagnosis*
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Schizotypal Personality Disorder / physiopathology
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Schizotypal Personality Disorder / psychology
Substances
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Dopamine Agents
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Dextroamphetamine
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Dopamine
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Norepinephrine