D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder

Schizophr Res. 1996 May;20(1-2):29-32. doi: 10.1016/0920-9964(95)00002-x.

Abstract

The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Arousal* / physiology
  • Attention* / physiology
  • Cognition Disorders / diagnosis
  • Cognition Disorders / physiopathology
  • Cognition Disorders / psychology
  • Dextroamphetamine*
  • Dopamine / physiology
  • Dopamine Agents*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests*
  • Norepinephrine / physiology
  • Problem Solving / physiology
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology
  • Schizotypal Personality Disorder / diagnosis*
  • Schizotypal Personality Disorder / physiopathology
  • Schizotypal Personality Disorder / psychology

Substances

  • Dopamine Agents
  • Dextroamphetamine
  • Dopamine
  • Norepinephrine