(+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes

Z Naturforsch C J Biosci. 1996 Jul-Aug;51(7-8):487-91.

Abstract

A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Calcium / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Dinoprostone / biosynthesis
  • Dinoprostone / blood
  • Fermentation
  • HL-60 Cells
  • HeLa Cells
  • Humans
  • In Vitro Techniques
  • Leukemia L1210
  • Leukocytes / drug effects
  • Leukocytes / metabolism*
  • Leukotriene Antagonists
  • Leukotriene C4 / biosynthesis
  • Leukotriene C4 / blood
  • Leukotrienes / biosynthesis*
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Polyporaceae*
  • Rats
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • 10-hydroxy-4-muurolen-3-one
  • Antineoplastic Agents, Phytogenic
  • Leukotriene Antagonists
  • Leukotrienes
  • Sesquiterpenes
  • Leukotriene C4
  • Dinoprostone
  • Calcium