Clinical information on serum IGFBP-3 levels and IGFBP-3 proteolytic activity in childhood

Prog Growth Factor Res. 1995;6(2-4):457-63. doi: 10.1016/0955-2235(96)00005-1.

Abstract

In this review paper, three pieces of clinical information in childhood are presented: (1) IGFBP-3 may replace GH provocation tests in the diagnosis of GH deficiency (GHD); (2) IGFBP-3 levels are regulated by IGF-I levels in a short period, and (3) ratio of free IGF-I to total IGF-I is high in serum of early infancy, similarly to serum of pregnancy, only partially owing to the presence of IGFBP-3 proteolytic activity. Each paper will be published soon.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Arginine
  • Child
  • Child, Preschool
  • Growth Disorders / diagnosis*
  • Human Growth Hormone / deficiency*
  • Human Growth Hormone / metabolism
  • Humans
  • Infant
  • Insulin
  • Insulin-Like Growth Factor Binding Protein 3 / metabolism*
  • Insulin-Like Growth Factor I / metabolism*

Substances

  • Insulin
  • Insulin-Like Growth Factor Binding Protein 3
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Arginine