Chronic intoxication with lead- and sulfur compounds may produce Parkinson's disease

J Neural Transm Suppl. 1995:46:183-7.

Abstract

Parkinson's disease was found in three post office workers who were in close contact with lead-sulfate batteries over a period between 1947 and 1983. The workers had been working in a charging station for lead storage batteries used for the battery-traction of post wagons. Parkinson's disease was diagnosed by the characteristic features of rigidity, tremor and elements of hypo-, brady- and akinesia. Additional symptoms were: bradyphrenia (n = 3), memory deficits (n = 3), depressive symptoms (n = 2) and peripheral neuropathy (n = 2). We hypothesize that the parkinsonian symptoms of these post office workers are primarily caused by lead or lead compounds. However a possible toxicity of sulfur containing compounds cannot be ruled out.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chronic Disease
  • Humans
  • Lead Poisoning / complications*
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Exposure*
  • Parkinson Disease, Secondary / chemically induced*
  • Sulfates / poisoning*

Substances

  • Sulfates