Cytogenetic and immunohistochemical evidence that giant cell fibroblastoma is related to dermatofibrosarcoma protuberans

P Dal Cin; R Sciot; I de Wever; P Brock; M Casteels-Van Daele; B Van Damme; H Van Den Berghe

doi:10.1002/(SICI)1098-2264(199601)15:1<73::AID-GCC10>3.0.CO;2-Q

Cytogenetic and immunohistochemical evidence that giant cell fibroblastoma is related to dermatofibrosarcoma protuberans

Genes Chromosomes Cancer. 1996 Jan;15(1):73-5. doi: 10.1002/(SICI)1098-2264(199601)15:1<73::AID-GCC10>3.0.CO;2-Q.

Authors

P Dal Cin¹, R Sciot, I de Wever, P Brock, M Casteels-Van Daele, B Van Damme, H Van Den Berghe

Affiliation

¹ Center for Human Genetics, University of Leuven, Belgium.

PMID: 8824728
DOI: 10.1002/(SICI)1098-2264(199601)15:1<73::AID-GCC10>3.0.CO;2-Q

Abstract

From cytogenetic and immunohistochemical findings in a primary giant cell fibrosarcoma and its recurrence, it is further demonstrated that a close relationship exists between this tumor and dermatofibrosarcoma protuberans. Both tumors express CD34 and show rearrangements of chromosomes 17 and 22.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD34 / genetics
Chromosome Aberrations*
Chromosome Disorders*
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 22
Dermatofibrosarcoma / genetics*
Dermatofibrosarcoma / metabolism
Female
Fibroma / genetics*
Fibroma / metabolism
Humans
Immunohistochemistry
Infant
Karyotyping
Male
Recurrence
Translocation, Genetic

Substances

Antigens, CD34