Generalized cutaneous reactions in association with radiotherapy have in the past been grouped into erythema multiforme (EM) and erythema multiforme-like reactions, the latter being reactions that do not strictly fit the accepted clinical and/or histological criteria for EM, yet have similar findings or presentations. Though usually benign and self-limiting, the progression to Stevens-Johnson syndrome, a potentially fatal form of erythema multiforme, has been reported. Presented here is a case study of a less severe radiation-induced erythema-like reaction.