An EcoRI RFLP in human APC gene

H Kurahashi; K Takami; I Yana; K Akagi; S Okada; I Nishisho

doi:10.1007/BF01900602

An EcoRI RFLP in human APC gene

Jpn J Hum Genet. 1995 Dec;40(4):339-41. doi: 10.1007/BF01900602.

Authors

H Kurahashi¹, K Takami, I Yana, K Akagi, S Okada, I Nishisho

Affiliation

¹ Department of Medical Genetics, Osaka University Medical School, Japan.

PMID: 8851769
DOI: 10.1007/BF01900602

Abstract

A novel EcoRI-restriction fragment length polymorphism in the genomic sequence of the human adenomatous polyposis coli (APC) gene is described. This polymorphism in the APC gene would be very useful for examination of segregation of the mutated APC gene in the kindreds of familial adenomatous polyposis, and also for studying the loss of heterozygosity at the APC region in certain tumors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Deoxyribonuclease EcoRI
Genes, APC / genetics*
Humans
Polymorphism, Restriction Fragment Length*

Substances

Deoxyribonuclease EcoRI