Successful management of hemolysis in ABO-nonidentical orthotopic liver transplantation by steroid therapy: a case report

Transpl Int. 1996;9(5):509-12. doi: 10.1007/BF00336831.

Abstract

Hemolysis due to donor-derived B lymphocytes has been reported in patients who have undergone ABO-nonidentical orthotopic liver transplantation (OLT). Yet, until now, little was known about the management of this transplantation-induced hemolysis. In this report we describe our experience with hemolysis in a patient after OLT. In addition, based on theoretical assumption, we hypothesize that corticosteroids can be helpful in the management of ABO-nonidentical OLT-induced hemolysis.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System / immunology*
  • Adoptive Transfer
  • Adrenal Cortex Hormones / therapeutic use*
  • Anemia, Hemolytic / drug therapy
  • Anemia, Hemolytic / etiology*
  • Antibodies, Anti-Idiotypic / immunology*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / transplantation
  • Blood Group Incompatibility / drug therapy
  • Blood Group Incompatibility / etiology*
  • Blood Transfusion
  • Graft Rejection / etiology
  • Graft Rejection / prevention & control
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Liver / cytology
  • Liver / immunology
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / immunology
  • Male
  • Middle Aged
  • Transplantation, Homologous / adverse effects

Substances

  • ABO Blood-Group System
  • Adrenal Cortex Hormones
  • Antibodies, Anti-Idiotypic
  • Immunosuppressive Agents