Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids

Enzyme Microb Technol. 1996 Apr;18(5):379-82. doi: 10.1016/0141-0229(95)00138-7.

Abstract

The inhibition of D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular alpha-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported. All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • Binding, Competitive
  • D-Amino-Acid Oxidase / antagonists & inhibitors*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Flavin-Adenine Dinucleotide / metabolism
  • Keto Acids / pharmacology*
  • Kidney / enzymology
  • Kinetics
  • Substrate Specificity
  • Swine / metabolism

Substances

  • Amino Acids
  • Enzyme Inhibitors
  • Keto Acids
  • Flavin-Adenine Dinucleotide
  • D-Amino-Acid Oxidase