Abstract
Endothelin-1, a potent endothelium-derived 21-amino acid vasoconstrictor peptide was only discovered relatively recently. Antagonism of its actions may provide an important new approach to the modulation of cardiac and vascular function.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cardiovascular Diseases / physiopathology
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Endothelin Receptor Antagonists
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Endothelin-1 / physiology
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Endothelins / antagonists & inhibitors
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Endothelins / physiology*
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Humans
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Renal Insufficiency / physiopathology
Substances
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Endothelin Receptor Antagonists
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Endothelin-1
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Endothelins