Specific skin infiltration as first sign of chronic myelomonocytic leukemia with an unusual phenotype

J Am Acad Dermatol. 1996 Nov;35(5 Pt 2):804-7. doi: 10.1016/s0190-9622(96)90088-2.

Abstract

A patient who had a plaque on his forehead as the first sign of chronic myelomonocytic leukemia (CMML) is described. Histologic studies, which formerly led to the misdiagnosis of non-Hodgkin's lymphoma, revealed CMML with an unusual phenotype. This represents a rare type of CMML for the following reasons: (1) specific cutaneous involvement is rarely the first sign of CMML; (2) the unique phenotype was detected by immunohistology on lesional skin, specifically, the leukemic infiltrate was CD4-positive and notably negative for CD15, the pan myeloid/monocytic marker.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Antigens, CD
  • Humans
  • Immunophenotyping
  • Leukemia, Myelomonocytic, Chronic / immunology
  • Leukemia, Myelomonocytic, Chronic / pathology*
  • Leukemic Infiltration*
  • Male
  • Skin / pathology*

Substances

  • Antigens, CD