Detectable levels of IgM antibodies to hepatitis C virus core protein predict breakthrough in patients with chronic hepatitis C treated with interferon-alpha

O Fracassetti; R Tambini; V Perani; O Vicari; N Lorenzi; G Delvecchio

doi:10.1111/j.1365-2893.1996.tb00053.x

Detectable levels of IgM antibodies to hepatitis C virus core protein predict breakthrough in patients with chronic hepatitis C treated with interferon-alpha

J Viral Hepat. 1996 Sep;3(5):265-6. doi: 10.1111/j.1365-2893.1996.tb00053.x.

Authors

O Fracassetti¹, R Tambini, V Perani, O Vicari, N Lorenzi, G Delvecchio

Affiliation

¹ Division of Infectious Diseases, Ospedali Riuniti, Bergamo, Italy.

PMID: 8914007
DOI: 10.1111/j.1365-2893.1996.tb00053.x

Abstract

The predictive value of IgM antibodies to hepatitis C virus core antigen (HCcAb) is controversial. We studied 79 patients undergoing interferon-alpha (IFN-alpha) treatment and we found that detectable levels of IgM HCcAb could predict breakthrough on treatment.

MeSH terms

Antiviral Agents / therapeutic use*
Hepatitis C / drug therapy*
Hepatitis C / immunology*
Hepatitis C Antibodies / analysis*
Humans
Immunoglobulin M / analysis*
Interferon-alpha / therapeutic use*
Predictive Value of Tests

Substances

Antiviral Agents
Hepatitis C Antibodies
Immunoglobulin M
Interferon-alpha