Threading your way to protein function

Chem Biol. 1996 Oct;3(10):779-83. doi: 10.1016/s1074-5521(96)90061-7.

Abstract

It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Enzymes / chemistry
  • Enzymes / physiology
  • Protein Structure, Secondary
  • Proteins / chemistry
  • Proteins / physiology*
  • Structure-Activity Relationship

Substances

  • Enzymes
  • Proteins