The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis

Cytogenet Cell Genet. 1996;74(3):225-6. doi: 10.1159/000134422.

Abstract

We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.1-->q22. Furthermore, we have shown that two YACs, known to contain the closest marker linked to neuronal ceroidlipofuscinosis (CLN5), also contains the Brn-3a gene. As one of these YACs is only 320 kb long, this localises POU4F1 within the critical region defining the CLN5 locus, and raises the possibility that POU4F1 is a candidate gene for CLN5.

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, Pair 13 / genetics*
  • DNA-Binding Proteins / genetics*
  • Humans
  • Hybrid Cells
  • Neuronal Ceroid-Lipofuscinoses / genetics*
  • Transcription Factor Brn-3
  • Transcription Factor Brn-3A
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • POU4F1 protein, human
  • Transcription Factor Brn-3
  • Transcription Factor Brn-3A
  • Transcription Factors