On the distribution of cholecystokinin B receptors in monkey brain

L D Mercer; P M Beart; M K Horne; D I Finkelstein; P Carrive; G Paxinos

doi:10.1016/s0006-8993(96)00477-5

On the distribution of cholecystokinin B receptors in monkey brain

Brain Res. 1996 Nov 4;738(2):313-8. doi: 10.1016/s0006-8993(96)00477-5.

Authors

L D Mercer¹, P M Beart, M K Horne, D I Finkelstein, P Carrive, G Paxinos

Affiliation

¹ Department of Pharmacology, Monash University, Clayton Vic., Australia.

PMID: 8955527
DOI: 10.1016/s0006-8993(96)00477-5

Abstract

In view of recent evidence for a role for the B subtype of cholecystokinin (CCKB) receptor in panic and anxiety, the distribution of CCKB receptors in the forebrain of a Rhesus macaca monkey was examined by receptor autoradiography employing [125I]D-Tyr25(Nleu28,31)-CCK25-33S. CCKB receptors were widely and topographically distributed in cortex. Other structures with notable labelling included the basal ganglia, presubiculum, amygdala, mamillary bodies, cerebellar cortex and pineal gland. The distribution of CCKB receptors further supports roles for this peptide in behavioural processes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Chemistry / physiology*
Corpus Striatum / chemistry
Diencephalon / chemistry
Female
Frontal Lobe / chemistry
Hippocampus / chemistry
Macaca mulatta
Mesencephalon / chemistry
Receptor, Cholecystokinin B
Receptors, Cholecystokinin / analysis*

Substances

Receptor, Cholecystokinin B
Receptors, Cholecystokinin