Hemolytic anemia provoked by recombinant alpha-interferon

J Gastroenterol. 1995 Dec;30(6):795-7. doi: 10.1007/BF02349651.

Abstract

A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the withdrawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic / diagnosis
  • Anemia, Hemolytic / drug therapy
  • Anemia, Hemolytic / etiology*
  • Antiviral Agents / adverse effects*
  • Antiviral Agents / therapeutic use
  • Female
  • Glucocorticoids / therapeutic use
  • Hepatitis C / therapy
  • Hepatitis, Chronic / therapy
  • Hepatitis, Chronic / virology
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / adverse effects*
  • Interferon-alpha / therapeutic use
  • Methylprednisolone / therapeutic use
  • Recombinant Proteins
  • Time Factors

Substances

  • Antiviral Agents
  • Glucocorticoids
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Methylprednisolone